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Inflammatory cytokines adversely affect different components of the central nervous system (CNS) and peripheral nervous system (PNS), which may, in turn, lead to degeneration of neurons and microglial cells, increased BBB permeability, as well as prolonged levels of microglial activation, which impairs neurogenesis (36, 37)

doi: 10.1371/journal.ppat.1001311 92 NairS

New York: Wiley-Liss

Non-steroidal topical therapies targeting phosphodiesterase-4 (PDE4) (e.g., crisaborole ointment) or Janus kinase (JAK) (e.g., ruxolitinib cream, a JAK1/2 inhibitor) have shown efficacy in several case reports of CHE

After 30, your body starts producing less glutathione

For most cases, oral supplements are effective if absorption issues are not severe, but your doctor may recommend injections for severe deficiency